Barbiturates and Benzodiazepines

Barbituratesand Benzodiazepines


Barbituratesand Benzodiazepines

Barbituratesand Benzodiazepines are sedative-hypnotic drugs that have been usedin the medical field to treat various diseases. Increased risks andadverse effects associated with barbiturate drugs have resulted inthe use of benzodiazepines, which is considerably safer. The essayfocuses on the attributed clinical problems and their effectivenessin treating diseases.



Asa result of a small safety margin, barbiturate use has reducedreplaced with benzodiazepines[ CITATION Hed06 l 1033 ].Barbiturates have numerous adverse health effects such as addiction,and delirium[ CITATION Hed06 l 1033 ].The psychological and physical dependence created by the drugsresults in a potentially fatal withdrawal condition accompanied byseizures. On the other hand, benzodiazepine drugs have a myriad ofside effects, including drowsiness, slurred speech, psychomotordifficulties, and vertigo among others[ CITATION Hed06 l 1033 ].Like the barbiturates, benzodiazepines also have a withdrawalsyndrome leading to headaches, agitation, and possible seizures.

Justificationfor their use

Barbituratedrugs have been used primarily for anesthesia and epilepsy diseases[ CITATION Hed06 l 1033 ].On the other hand, benzodiazepines treat anxiety, insomnia, socialand simple phobia, anesthesia, and panic disorder among others. Thesedrugs have a sedating and culminatingeffect that makes them suitable for use in treating insomnia andanxiety[ CITATION Hed06 l 1033 ].Barbiturates and Benzodiazepine drugs interact with the GABA receptorin the brain to allow flood chloride ions. The metabolism process isundertaken by the cytochrome P450 enzymes, increasing enzymeactivities and reducing blood levels[ CITATION Hed06 l 1033 ].GABA neurotransmitter is responsible for lagged neuron activities.


Despitetheir positive health effects in treating various diseases, theBarbiturates and Benzodiazepine drugs have severe adverse impactsthat require physician attention. Addiction problems resulting fromthe use of the sedative-hypnotic drugs require medical attention toavoid deterioration of health.


Hedges, D., &amp Burchfield, C. (2006). Mind, Brain, and Drug: An Introduction to Psychopharmacology. Michigan: Pearson/Allyn and Bacon.